A Case of Multicentric Gliomatosis Cerebri Diagnosed with Brain Biopsy

Glioma is a type of primary central nervous system (CNS) tumor that arises from glial cells. Although gliomatosis cerebri (GC) is a subtype of the CNS glioma, it is distinct from other tumors of glial origin and classified as neuroepithelial tumor of uncertain origin. Primary GC shows diffuse infiltration of neoplastic glial cells through more than two cerebral lobes or the infratentorial structures in the absence of any identifiable tumor mass. Because neoplastic cells infiltrate the cerebral lobes with relatively mild destruction of the architecture of normal surrounding tissues, clinical symptoms of GC might be very subtle in contrast to its radiological findings. The GC has non-specific clinical presentations such as headache, seizure, memory impairment, confusion, unsteady gait, nausea, dizziness and vomiting. GC is a rare disease and multicentric GC was exceedingly uncommon among hundreds of reported cases with GC. We report a case of non-contiguous GC confirmed with the brain biopsy.